A missed approval deadline is not a locking factor. However, to avoid elapsed deadlines, Approvers are sent a reminder message both 24 hours prior to and on the actual deadline. If a deadline is still not met, the respective request will be marked as Overdue in the list of requests.
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Organisation Administrators, Requesters, Reviewers and Approvers can send reminders (email notifications) to Approvers and/or Reviewers who haven't yet acted on a request.